HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-5-iodopyrazine → N-Cyclopropyl-N-[1-(5-iodo-pyrazin-2-yl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-5-iodopyrazine | HCID 21931200 | — |
| Reactant | N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride | HCID 68289930 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | N-Cyclopropyl-N-[1-(5-iodo-pyrazin-2-yl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide | HCID 86678216 | — |
Reaction Steps
The title compound is prepared from N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride and 2-bromo-5-iodo-pyrazine following a procedure analogous to that described in Example 19 using N-methylpyrrolidinone as solvent. LC (method 16): tR=0.51 min; Mass spectrum (ESI+): m/z=516 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822471B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-95ea0f404a6c4564a47301583b8d7d30 |
| Source note | uspto-grants-2014_09 |