PyBroP → HCID 68351888, compound

Participants

Reaction Steps

Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate (PyBrOP, 14 mg) in N,N-dimethylformamide (0.1 mL) is added to a solution of cyclopropyl-(3′-fluoro-5′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-amine (6 mg), 4-(2-methyl-imidazol-1-yl)-benzoic acid (6 mg), and triethylamine (0.015 mL) in N,N-dimethylformamide (0.4 mL) at room temperature. The solution is stirred for 2 h and then submitted to chromatography on reversed phase (HPLC, acetonitrile/water/trifluoroacetic acid) to give the pure title compound. LC (method 19): tR=4.33 min; Mass spectrum (ESI+): m/z=488 [M+H]+.

Provenance & Evidence