3-Fluoro-4-(2-methyl-imidazol-1-yl)-benzoic acid → HCID 68351914, compound

HRID 68888Notes

Reaction equation

HRID 68888 reaction equation
[CH:1]1([NH:4][CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[C:16]([F:17])=[CH:15][C:14]([C:18]([F:21])([F:20])[F:19])=[CH:13][N:12]=3)[CH2:7][CH2:6]2)[CH2:3][CH2:2]1.[F:22][C:23]1[CH:24]=[C:25]([CH:29]=[CH:30][C:31]=1[N:32]1[CH:36]=[CH:35][N:34]=[C:33]1[CH3:37])[C:26](O)=[O:27]>>[CH:1]1([N:4]([CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[C:16]([F:17])=[CH:15][C:14]([C:18]([F:20])([F:19])[F:21])=[CH:13][N:12]=3)[CH2:7][CH2:6]2)[C:26](=[O:27])[C:25]2[CH:29]=[CH:30][C:31]([N:32]3[CH:36]=[CH:35][N:34]=[C:33]3[CH3:37])=[C:23]([F:22])[CH:24]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 286046533-Fluoro-4-(2-methyl-imidazol-1-yl)-benzoic acidHCID 68289864Cyclopropyl-(3'-fluoro-5'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-amine

Product 1

HCID 68351914HCID 68351914, compound

Procedure

The title compound is prepared from cyclopropyl-(3′-fluoro-5′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-amine and 3-fluoro-4-(2-methyl-imidazol-1-yl)-benzoic acid following a procedure analogous to that described in Example 90. LC (method 19): tR=4.71 min; Mass spectrum (ESI+): m/z=506 [M+H]+.

Sources & evidence

ORD record
ord-f9f22bd6b1c54b88bd1c1a011da111e4
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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