4-(1H-1,2,4-Triazol-1-yl)benzoic acid → N-Cyclopropyl-N-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-4-[1,2,4]triazol-1-yl-benzamide

HRID 68892Notes

Reaction equation

HRID 68892 reaction equation
[CH:1]1([NH:4][CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[O:15][N:14]=[C:13]([CH:16]([CH3:18])[CH3:17])[N:12]=3)[CH2:7][CH2:6]2)[CH2:3][CH2:2]1.[N:19]1([C:24]2[CH:32]=[CH:31][C:27]([C:28](O)=[O:29])=[CH:26][CH:25]=2)[CH:23]=[N:22][CH:21]=[N:20]1>>[CH:1]1([N:4]([CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[O:15][N:14]=[C:13]([CH:16]([CH3:18])[CH3:17])[N:12]=3)[CH2:7][CH2:6]2)[C:28](=[O:29])[C:27]2[CH:26]=[CH:25][C:24]([N:19]3[CH:23]=[N:22][CH:21]=[N:20]3)=[CH:32][CH:31]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 7365314-(1H-1,2,4-Triazol-1-yl)benzoic acidHCID 68290028N-cyclopropyl-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-amine

Product 1

HCID 71293491N-Cyclopropyl-N-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-4-[1,2,4]triazol-1-yl-benzamide

Procedure

The title compound is prepared from cyclopropyl-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amine and 4-[1,2,4]triazol-1-yl-benzoic acid following a procedure analogous to that described in Example 90. LC (method 19): tR=3.71 min; Mass spectrum (ESI+): m/z=422 [M+H]+.

Sources & evidence

ORD record
ord-32ce4f4c49da42ae83341c790e9f276d
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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