HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 68290560, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 4-(2-methyl-1H-imidazol-1-yl)benzoic acid | HCID 13815988 | — |
| Reactant | Water TFA acetonitrile | HCID 22145617 | — |
| Reactant | 1-(5-chloropyrimidin-2-yl)-N-cyclopropylpiperidin-4-amine | HCID 68289573 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 68290560 | HCID 68290560 | — |
Reaction Steps
1-(3-Dimethylamino-propyl)-3-ethyl-carbodiimide (EDC, 12 mg) in N,N-dimethylformamide (0.1 mL) is added to a solution of [1-(5-chloro-pyrimidin-2-yl)-piperidin-4-yl]-cyclopropyl-amine (5 mg), 4-(2-methyl-imidazol-1-yl)-benzoic acid (6 mg), 1-hydroxy-benzo-triazole (3 mg), and triethylamine (15 μL) in N,N-dimethylformamide (0.4 mL) at room temperature. The solution is stirred for 18 h and then submitted to chromatography on reversed phase (HPLC, acetonitrile/water/trifluoroacetic acid) to give the pure title compound. LC (method 19): tR=3.97 min; Mass spectrum (ESI+): m/z=437 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822471B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-931b37d612b54daeb113ad35abece5a9 |
| Source note | uspto-grants-2014_09 |