1-(5-chloropyrimidin-2-yl)-N-cyclopropylpiperidin-4-amine → N-[1-(5-Chloro-pyrimidin-2-yl)-piperidin-4-yl]-N-cyclopropyl-4-(5-methyl-[1,2,4]triazol-1-yl)-benzamide

HRID 68904Notes

Reaction equation

HRID 68904 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([NH:14][CH:15]3[CH2:17][CH2:16]3)[CH2:10][CH2:9]2)=[N:6][CH:7]=1.[CH3:18][C:19]1[N:23]([C:24]2[CH:32]=[CH:31][C:27]([C:28](O)=[O:29])=[CH:26][CH:25]=2)[N:22]=[CH:21][N:20]=1>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([N:14]([CH:15]3[CH2:17][CH2:16]3)[C:28](=[O:29])[C:27]3[CH:26]=[CH:25][C:24]([N:23]4[C:19]([CH3:18])=[N:20][CH:21]=[N:22]4)=[CH:32][CH:31]=3)[CH2:10][CH2:9]2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 682895731-(5-chloropyrimidin-2-yl)-N-cyclopropylpiperidin-4-amineHCID 682895874-(5-Methyl-1H-1,2,4-triazol-1-yl)benzoic acid

Product 1

HCID 71293476N-[1-(5-Chloro-pyrimidin-2-yl)-piperidin-4-yl]-N-cyclopropyl-4-(5-methyl-[1,2,4]triazol-1-yl)-benzamide

Procedure

The title compound is prepared from [1-(5-chloro-pyrimidin-2-yl)-piperidin-4-yl]-cyclopropyl-amine and 4-(5-methyl-[1,2,4]triazol-1-yl)-benzoic acid following a procedure analogous to that described in Example 107. LC (method 19): tR=3.79 min; Mass spectrum (ESI+): m/z=438 [M+H]+.

Sources & evidence

ORD record
ord-7a0ff51a5d1a473990fe47adbff741d8
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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