4-(1H-1,2,3,4-tetrazol-1-yl)benzoic acid → N-[1-(5-Chloro-pyrimidin-2-yl)-piperidin-4-yl]-N-cyclopropyl-4-tetrazol-1-yl-benzamide

HRID 68905Notes

Reaction equation

HRID 68905 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([NH:14][CH:15]3[CH2:17][CH2:16]3)[CH2:10][CH2:9]2)=[N:6][CH:7]=1.[N:18]1([C:23]2[CH:31]=[CH:30][C:26]([C:27](O)=[O:28])=[CH:25][CH:24]=2)[CH:22]=[N:21][N:20]=[N:19]1>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([N:14]([CH:15]3[CH2:17][CH2:16]3)[C:27](=[O:28])[C:26]3[CH:30]=[CH:31][C:23]([N:18]4[CH:22]=[N:21][N:20]=[N:19]4)=[CH:24][CH:25]=3)[CH2:10][CH2:9]2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 6741614-(1H-1,2,3,4-tetrazol-1-yl)benzoic acidHCID 682895731-(5-chloropyrimidin-2-yl)-N-cyclopropylpiperidin-4-amine

Product 1

HCID 68351956N-[1-(5-Chloro-pyrimidin-2-yl)-piperidin-4-yl]-N-cyclopropyl-4-tetrazol-1-yl-benzamide

Procedure

The title compound is prepared from [1-(5-chloro-pyrimidin-2-yl)-piperidin-4-yl]-cyclopropyl-amine and 4-tetrazol-1-yl-benzoic acid following a procedure analogous to that described in Example 107. LC (method 19): tR=4.05 min; Mass spectrum (ESI+): m/z=425 [M+H]+.

Sources & evidence

ORD record
ord-df56b27cfbcf4d92b2e82b26e33086d1
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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