HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-fluoro-4-(1H-1,2,4-triazol-1-yl)benzoic acid → N-[1-(5-Chloro-pyrimidin-2-yl)-piperidin-4-yl]-N-cyclopropyl-3-fluoro-4-[1,2,4]triazol-1-yl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-fluoro-4-(1H-1,2,4-triazol-1-yl)benzoic acid | HCID 28604576 | — |
| Reactant | 1-(5-chloropyrimidin-2-yl)-N-cyclopropylpiperidin-4-amine | HCID 68289573 | — |
| Product | N-[1-(5-Chloro-pyrimidin-2-yl)-piperidin-4-yl]-N-cyclopropyl-3-fluoro-4-[1,2,4]triazol-1-yl-benzamide | HCID 68351940 | — |
Reaction Steps
The title compound is prepared from [1-(5-chloro-pyrimidin-2-yl)-piperidin-4-yl]-cyclopropyl-amine and 3-fluoro-4-[1,2,4]triazol-1-yl-benzoic acid following a procedure analogous to that described in Example 107. LC (method 19): tR=4.00 min; Mass spectrum (ESI+): m/z=442 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822471B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-f6bbfbd6efd94dadb5317d79017cb332 |
| Source note | uspto-grants-2014_09 |