4-(1H-1,2,3,4-tetrazol-1-yl)benzoic acid → N-Cyclopropyl-N-(3'-fluoro-5'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-4-tetrazol-1-yl-benzamide

HRID 68912Notes

Reaction equation

HRID 68912 reaction equation
[CH:1]1([NH:4][CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[C:16]([F:17])=[CH:15][C:14]([C:18]([F:21])([F:20])[F:19])=[CH:13][N:12]=3)[CH2:7][CH2:6]2)[CH2:3][CH2:2]1.[N:22]1([C:27]2[CH:35]=[CH:34][C:30]([C:31](O)=[O:32])=[CH:29][CH:28]=2)[CH:26]=[N:25][N:24]=[N:23]1>>[CH:1]1([N:4]([CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[C:16]([F:17])=[CH:15][C:14]([C:18]([F:20])([F:19])[F:21])=[CH:13][N:12]=3)[CH2:7][CH2:6]2)[C:31](=[O:32])[C:30]2[CH:34]=[CH:35][C:27]([N:22]3[CH:26]=[N:25][N:24]=[N:23]3)=[CH:28][CH:29]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 6741614-(1H-1,2,3,4-tetrazol-1-yl)benzoic acidHCID 68289864Cyclopropyl-(3'-fluoro-5'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-amine

Product 1

HCID 71293501N-Cyclopropyl-N-(3'-fluoro-5'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-4-tetrazol-1-yl-benzamide

Procedure

The title compound is prepared from cyclopropyl-(3′-fluoro-5′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-amine and 4-tetrazol-1-yl-benzoic acid following a procedure analogous to that described in Example 107. LC (method 19): tR=4.46 min; Mass spectrum (ESI+): m/z=476 [M+H]+.

Sources & evidence

ORD record
ord-724c36917936496baa318e33de8c4411
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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