Nitric Acid → HCID 178418837, compound

HRID 6892Notes

Reaction equation

HRID 6892 reaction equation
[N+:1]([O-:4])(O)=[O:2].[CH3:5][C:6]1[N:14]=[C:13]([CH3:15])[CH:12]=[C:11]([OH:16])[C:7]=1[C:8]([OH:10])=[O:9]>S(=O)(=O)(O)O>[CH3:5][C:6]1[N:14]=[C:13]([CH3:15])[C:12]([N+:1]([O-:4])=[O:2])=[C:11]([OH:16])[C:7]=1[C:8]([OH:10])=[O:9]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 1784187324-Hydroxy-2,6-dimethylnicotinic acid

Product 1

HCID 178418837HCID 178418837, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

20 ml of 90% nitric acid is added to 100 ml of 98% sulphuric acid with stirring and cooling. To this solution is added portion-wise 6.9 g (41.1 mmol) of 2,6-dimethyl-4-hydroxy-nicotinic acid. The mixture is stirred at 80° C. for 1 hour, cooled down and added cautiously 300 g of crushed ice. The resulting suspension is filtered off. The cake is washed with water and dried. There is obtained 6.7 g (77%) of a white solid.

Workup

  1. temperaturecooling
  2. stirringThe mixture is stirred at 80° C. for 1 hour
  3. temperaturecooled down
  4. filtrationThe resulting suspension is filtered off
  5. washThe cake is washed with water
  6. customdried

Sources & evidence

ORD record
ord-72534ca11d814b16ab1a292f213777db
Source dataset
uspto-grants-2006_08
Patent number
US07084163B2

Reaction notes

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