(3-Chlorophenyl)boronic acid → 5-(3-chloro-phenyl)-N-(2-cyclopropyl-2-hydroxy-propyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide

HRID 689788Notes

Reaction equation

HRID 689788 reaction equation
[Br:1][c:2]1[c:3]([O:22][CH2:23][C:24]([F:25])([F:26])[F:27])[n:4][c:5]([C:18]([F:19])([F:20])[F:21])[c:6]([C:7](=[O:8])[NH:9][CH2:10][C:11]([CH3:12])([OH:13])[CH:14]2[CH2:15][CH2:16]2)[cH:17]1.[Cl:28][c:29]1[cH:30][c:31]([B:35]([OH:36])[OH:37])[cH:32][cH:33][cH:34]1>>[c:2]1(-[c:31]2[cH:30][c:29]([Cl:28])[cH:34][cH:33][cH:32]2)[c:3]([O:22][CH2:23][C:24]([F:25])([F:26])[F:27])[n:4][c:5]([C:18]([F:19])([F:20])[F:21])[c:6]([C:7](=[O:8])[NH:9][CH2:10][C:11]([CH3:12])([OH:13])[CH:14]2[CH2:15][CH2:16]2)[cH:17]1

Participants

3

Reactant 2

HCID 2734323(3-Chlorophenyl)boronic acidHCID 866347985-Bromo-N-(2-cyclopropyl-2-hydroxy-propyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide

Product 1

HCID 442407235-(3-chloro-phenyl)-N-(2-cyclopropyl-2-hydroxy-propyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide

Sources & evidence

ORD record
ord-0f088d2b5dfa461593d99c40a67137e9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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