Dichloromethane → 1-(3-tert-butyl-1-(4-(methylsulfonyl)phenyl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(3-oxo-3,4-dihydropyrido[3,2-b]pyrazin-8-yloxy)phenyl)urea

HRID 690004Notes

Reaction equation

HRID 690004 reaction equation
[C:21]([CH3:22])([CH3:23])([CH3:24])[c:25]1[n:26][n:27](-[c:33]2[cH:34][cH:35][c:36]([S:39](=[O:40])(=[O:41])[CH3:42])[cH:37][cH:38]2)[c:28]([N:30]=[C:31]=[O:32])[cH:29]1.[Cl:43][CH2:44][Cl:45].[NH2:1][c:2]1[c:3]([F:20])[cH:4][c:5]([O:6][c:7]2[cH:8][cH:9][n:10][c:11]3[nH:12][c:13](=[O:17])[cH:14][n:15][c:16]23)[cH:18][cH:19]1>>[NH:1]([c:2]1[c:3]([F:20])[cH:4][c:5]([O:6][c:7]2[cH:8][cH:9][n:10][c:11]3[nH:12][c:13](=[O:17])[cH:14][n:15][c:16]23)[cH:18][cH:19]1)[C:31]([NH:30][c:28]1[n:27](-[c:33]2[cH:34][cH:35][c:36]([S:39](=[O:40])(=[O:41])[CH3:42])[cH:37][cH:38]2)[n:26][c:25]([C:21]([CH3:22])([CH3:23])[CH3:24])[cH:29]1)=[O:32]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 469009328-(4-amino-3-fluorophenoxy)pyrido[2,3-b]pyrazin-3(4H)-oneHCID 866479003-tert-butyl-5-isocyanato-1-(4-(methylsulfonyl)phenyl)-1H-pyrazole

Product 1

HCID 441320421-(3-tert-butyl-1-(4-(methylsulfonyl)phenyl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(3-oxo-3,4-dihydropyrido[3,2-b]pyrazin-8-yloxy)phenyl)urea

Sources & evidence

ORD record
ord-344253bce5c54a20af5f4cf662d172b5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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