反应详情

温度

50 °C

A 1N-sodium hydroxide aqueous solution (0.72 ml) was added to a methanol solution (2 ml) of 4-{[[5-(1-methyl-2-oxo-1,2-dihydroquinolin-6-yloxy)pentyl]-(2-pyridin-3-ylethyl)amino]methyl}benzoic acid methyl ester (153 mg). The mixture was stirred at 50° C. for 3 hours. The reaction mixture was condensed under reduced pressure. Water was added to the residue, and acetic acid was added for neutralization. The mixture was extracted using dichloromethane. The organic layer was dried with anhydrous sodium sulfate, and condensed under reduced pressure. Diisopropyl ether was added to the residue. The generated insoluble matter was separated by filtration and dried to give the title compound (115 mg) as a white powder.

1. customcondensed under reduced pressure
2. additionwas added for neutralization
3. extractionThe mixture was extracted
4. dry with materialThe organic layer was dried with anhydrous sodium sulfate, and condensed under reduced pressure
5. additionDiisopropyl ether was added to the residue
6. customThe generated insoluble matter was separated by filtration
7. customdried