反应详情

温度

60 °C

6-Aminoquinoline (360 mg) was added to the methanol solution (10 ml) of 6-(3-iodopropoxy)-1-methyl-1H-quinolin-2-one (172 mg) and stirred at 60° C. for 17 hours. The reaction mixture was added to ice water, and extraction with dichloromethane was performed. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:methanol=10:0→4:1). The purified product was condensed under reduced pressure to give the title compound (86.4 mg) as a yellow amorphous solid.

1. dry with materialThe organic layer was dried over anhydrous sodium sulfate
2. concentrationconcentrated under reduced pressure
3. customThe residue was purified by silica gel column chromatography (ethyl acetate:methanol=10:0→4:1)
4. customcondensed under reduced pressure