4-Phenylpiperidin-4-ol → 2,2,2-Trifluoro-1-[6-(4-hydroxy-4-phenyl-piperidin-1-yl)-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-ethanone

HRID 691164Notes

Reaction equation

HRID 691164 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5](-[c:19]3[cH:20][cH:21][c:22]([S:25](=[O:26])(=[O:27])[CH3:28])[cH:23][cH:24]3)[c:6]([C:13]([C:14]([F:15])([F:16])[F:17])=[O:18])[c:7]([CH3:12])[n:8][c:9]2[cH:10][cH:11]1.[OH:29][C:30]1([c:36]2[cH:37][cH:38][cH:39][cH:40][cH:41]2)[CH2:31][CH2:32][NH:33][CH2:34][CH2:35]1>>[c:2]1([N:33]2[CH2:32][CH2:31][C:30]([OH:29])([c:36]3[cH:37][cH:38][cH:39][cH:40][cH:41]3)[CH2:35][CH2:34]2)[cH:3][c:4]2[c:5](-[c:19]3[cH:20][cH:21][c:22]([S:25](=[O:26])(=[O:27])[CH3:28])[cH:23][cH:24]3)[c:6]([C:13]([C:14]([F:15])([F:16])[F:17])=[O:18])[c:7]([CH3:12])[n:8][c:9]2[cH:10][cH:11]1

Participants

3

Reactant 2

HCID 963874-Phenylpiperidin-4-olHCID 115400851-[6-Bromo-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone

Product 1

HCID 675498522,2,2-Trifluoro-1-[6-(4-hydroxy-4-phenyl-piperidin-1-yl)-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-ethanone

Sources & evidence

ORD record
ord-267f41fc0eb54a9a9d527b6581f1a996
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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