Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 2-Amino-4-fluoropyridine | HCID 18327808 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | 5-Bromo-4-fluoropyridin-2-amine hydrochloride | HCID 71627067 | — |
Reaction Steps
To mono HCl salt of 4-fluoro-pyridin-2-ylamine (xviii) (3 g, 20.2 mmol) in acetonitrile at 0° C. was added in 3 portions N-bromosuccinimide (3.59 g, 20.2 mmol) over 1.5 h. The RM was stirred 1 h at 0° C. and the precipitate was filtered and dried under vacuo to give the title compound as mono HCl salt (tR 1.61 min (conditions 8), MH+=191, 193).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08822468B2 |
|---|
| Source dataset | uspto-grants-2014_09 |
|---|
| ORD ID | ord-f1ba03fead814deb8191e94a2db9d828 |
|---|
| Source note | uspto-grants-2014_09 |
|---|
