Water → (6-Chloroimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanol

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Reaction Steps

Sodium borohydride (103 mg, 2.62 mmol) was added to a solution of (6-chloro-imidazo[1,2-b]pyridazin-3-yl)-quinolin-6-yl-methanone (Stage 1.2, 1.62 g, 5.25 mmol) in ethanol (17 mL) and the solution was stirred at rt for 4 h. Water was then added and the mixture extracted with 9:1 DCM/MeOH. The organic extracts were dried, filtered and concentrated to afford the title compound as a brown solid (tR 1.0 min (conditions 1), MH+=311).

Provenance & Evidence