反应详情

温度

100 °C

Bromine (6.69 g, 132 mmol) was added to a warm (100° C.) solution of 1-quinolin-6-yl-ethanone (Stage 1.4, 18.8 g, 110 mmol) in acetic acid (50 mL). The mixture was stirred at 100° C. for 45 min then cooled to rt. A precipitate was formed which was filtered off and washed with Et2O. Drying under HV at 50° C. afforded the title compound as a brown solid (tR 1.3 min (conditions 1), MH+=251.8).

1. temperaturethen cooled to rt
2. customA precipitate was formed which
3. filtrationwas filtered off
4. washwashed with Et2O
5. customDrying under HV at 50° C.