Ethyl 5-bromo-4-(3-chlorophenyl)-1,3-thiazole-2-carboxylate → 5-(3-Chloro-5-fluorophenyl)-4-(3-chlorophenyl)-1,3-thiazole-2-carboxylic acid

HRID 691551Notes

Reaction equation

HRID 691551 reaction equation
[Br:25][c:26]1[s:27][c:28]([C:29]([O:30][CH2:31][CH3:32])=[O:33])[n:34][c:35]1-[c:36]1[cH:37][cH:38][cH:39][c:40]([Cl:41])[cH:42]1.[Cl:1][c:2]1[cH:3][c:4](-[c:9]2[n:10][c:11]([C:22](=[O:23])[OH:24])[s:12][c:13]2-[c:14]2[cH:15][c:16]([Cl:21])[cH:17][c:18]([F:20])[cH:19]2)[cH:5][cH:6][c:7]1[F:8]>>[Cl:1][c:2]1[cH:3][c:4](-[c:9]2[n:10][c:11]([C:22](=[O:23])[OH:24])[s:12][c:13]2-[c:14]2[cH:15][c:16]([Cl:21])[cH:17][c:18]([F:20])[cH:19]2)[cH:5][cH:6][cH:7]1

Participants

3

Reactant 2

HCID 70801641Ethyl 5-bromo-4-(3-chlorophenyl)-1,3-thiazole-2-carboxylateHCID 708016444-(3-Chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-carboxylic acid

Product 1

HCID 708016405-(3-Chloro-5-fluorophenyl)-4-(3-chlorophenyl)-1,3-thiazole-2-carboxylic acid

Sources & evidence

ORD record
ord-400dd793ddf44432b5a4d6cf1cc09ffc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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