3,3,3-Trifluoro-2-hydroxypropanoic acid → trans-(RS)-N-(4-{2-[4-(2,3-Dihydro-furo[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexyl)-3,3,3-trifluoro-2-hydroxy-propionamide

HRID 691611Notes

Reaction equation

HRID 691611 reaction equation
[F:31][C:32]([CH:33]([C:34](=[O:35])[OH:36])[OH:37])([F:38])[F:39].[O:1]1[CH2:2][CH2:3][c:4]2[c:5]([N:10]3[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][CH:18]4[CH2:19][CH2:20][CH:21]([NH:24][C:25](=[O:26])[CH2:27][CH:28]=[CH:29][CH3:30])[CH2:22][CH2:23]4)[CH2:14][CH2:15]3)[n:6][cH:7][cH:8][c:9]21>>[O:1]1[CH2:2][CH2:3][c:4]2[c:5]([N:10]3[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][CH:18]4[CH2:19][CH2:20][CH:21]([NH:24][C:34]([CH:33]([C:32]([F:31])([F:38])[F:39])[OH:37])=[O:35])[CH2:22][CH2:23]4)[CH2:14][CH2:15]3)[n:6][cH:7][cH:8][c:9]21

Participants

3

Reactant 2

HCID 2448963,3,3-Trifluoro-2-hydroxypropanoic acidHCID 77184361N-[4-[2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)piperazin-1-yl]ethyl]cyclohexyl]pent-3-enamide

Product 1

HCID 54771512trans-(RS)-N-(4-{2-[4-(2,3-Dihydro-furo[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexyl)-3,3,3-trifluoro-2-hydroxy-propionamide

Sources & evidence

ORD record
ord-2485a8a85f3f40518cd307341967bacd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…