(3R)-3-fluoropyrrolidine hydrochloride → 6-[6-((s)-3-Fluoro-pyrrolidin-1-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline

Participants

Reaction Steps

The title compound was prepared in analogy to the compound of Example 124 using (S)-(+)-3-fluoropyrrolidine hydrochloride as starting material instead of (R)-(−)-3-fluoropyrrolidine hydrochloride (tR 3.89 min (conditions 4), MH+=348.2, 1H-NMR in DMSO-d6: 8.84 (m, 1H); 8.29 (m, 1H); 7.92 (m, 2H); 7.81 (d, 1H); 7.75 (m, 1H); 7.49 (dd, 1H); 7.43 (s, 1H); 6.81 (d, 1H); 5.46 (m, 1H); 4.38 (s, 2H); 3.62 (m, 4H); 2.21 (m, 2H)).

Provenance & Evidence