2-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acid → 2-Phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid [6-(3-hydroxy-pyrrolidin-1-yl)-pyridin-3-yl]amide

HRID 692075Notes

Reaction equation

HRID 692075 reaction equation
[NH2:19][c:20]1[cH:21][cH:22][c:23]([N:26]2[CH2:27][CH:28]([OH:31])[CH2:29][CH2:30]2)[n:24][cH:25]1.[c:1]1(-[c:7]2[o:8][c:9]([C:15]([F:16])([F:17])[F:18])[c:10]([C:12](=[O:13])[OH:14])[n:11]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1(-[c:7]2[o:8][c:9]([C:15]([F:16])([F:17])[F:18])[c:10]([C:12](=[O:14])[NH:19][c:20]3[cH:21][cH:22][c:23]([N:26]4[CH2:27][CH:28]([OH:31])[CH2:29][CH2:30]4)[n:24][cH:25]3)[n:11]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

3

Reactant 2

HCID 27764382-Phenyl-5-(trifluoromethyl)-oxazole-4-carboxylic acidHCID 534081671-(5-Aminopyridin-2-yl)pyrrolidin-3-ol

Product 1

HCID 593013462-Phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid [6-(3-hydroxy-pyrrolidin-1-yl)-pyridin-3-yl]amide

Sources & evidence

ORD record
ord-d78cd617b8014ffe9cee90c65627d953
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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