[5-(4-Chloro-phenyl)-3-iodo-pyrazolo[1,5-a]pyrimidin-7-yl]-methanol → 2-(4-[5-(4-Chloro-phenyl)-7-hydroxymethyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-phenyl}-propan-2-ol

HRID 692229Notes

Reaction equation

HRID 692229 reaction equation
[C:20](#[CH:21])[c:22]1[cH:23][cH:24][c:25]([C:28]([CH3:29])([CH3:30])[OH:31])[cH:26][cH:27]1.[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[n:11]([c:12]([CH2:14][OH:15])[cH:13]2)[n:16][cH:17][c:18]3[I:19])[cH:6][cH:7]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[n:11]([c:12]([CH2:14][OH:15])[cH:13]2)[n:16][cH:17][c:18]3[C:21]#[C:20][c:22]2[cH:23][cH:24][c:25]([C:28]([CH3:29])([CH3:30])[OH:31])[cH:26][cH:27]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 67001059[5-(4-Chloro-phenyl)-3-iodo-pyrazolo[1,5-a]pyrimidin-7-yl]-methanolHCID 730124462-(4-Ethynylphenyl)propan-2-ol

Product 1

HCID 118523112-(4-[5-(4-Chloro-phenyl)-7-hydroxymethyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-phenyl}-propan-2-ol

Sources & evidence

ORD record
ord-978585d8c7c442d18db3d6bfb177fa5a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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