Triacetoxyperiodinane → (6-Chloro-imidazo[1,2-b]pyridazin-3-yl)-(5,7-difluoro-quinolin-6-yl)-methanone

Participants

Reaction Steps

(rac)-(6-Chloro-imidazo[1,2-b]pyridazin-3-yl)-(5,7-difluoro-quinolin-6-yl)-methanol (Stage 182.4, 3.0 g, 8.65 mmol) was dissolved in DCM (87 mL) and Dess-Martin periodinane (4.40 g, 10.38 mmol) was added. The RM was stirred for 3 h at rt. The solvent was removed and the residue was then taken up with EtOAc and washed with 2.5 M NaOH and with brine. The organic layer was then dried over Na2SO4 and the solvent was removed to give the title compound as a brown solid (tR 1.2 min (conditions 2), MH+=345).

Provenance & Evidence