反应详情

(rac)-(5,7-Difluoro-quinolin-6-yl)-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-methanol (Stage 191.3, 1.0 g, 2.55 mmol) was dissolved in DCM (25.5 mL) and Dess-Martin periodinane (1.621 g, 3.82 mmol) was added. The RM was stirred for 1 h at rt and then 2.5 M NaOH solution was added. The RM was extracted with EtOAc/MeOH (9:1) twice. The organics were joined and washed with brine, dried over Na2SO4 and the solvent was removed. The residue was purified by MPLC with DCM and MeOH to afford a light yellow solid as the title compound (tR 1.2 min (conditions 2), MH+=391)

1. extractionThe RM was extracted with EtOAc/MeOH (9:1) twice
2. washwashed with brine
3. dry with materialdried over Na2SO4
4. customthe solvent was removed
5. customThe residue was purified by MPLC with DCM and MeOH