Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) → 7-Fluoro-6-{6-[1-(2-morpholin-4-yl-ethyl)-1h-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-ylmethyl}-quinoline

Participants

Reaction Steps

The title compound was prepared in analogy to the compound of Example 231 using 2-chlorethyl-morpholine hydrochloride instead of 1-(2-chlorethyl)pyrrolidine hydrochloride and with a second flash chromatography purification afterwards (tR 3.04 min (conditions 3), MH+=458.2, 1H-NMR in DMSO-d6: 8.84 (m, 1H); 8.44 (s, 1H); 8.33 (d, 1H); 8.09 (m, 2H); 8.01 (d, 1H); 7.76 (d, 1H); 7.62 (m, 1H); 7.52 (d, 1H); 7.46 (dd, 1H); 4.54 (s, 2H); 4.28 (t, 2H); 3.50 (m, 4H); 2.72 (m, 2H); 2.39 (m, 4H)).

Provenance & Evidence