1-[2-(4-Aminopiperidin-1-yl)ethyl]-2-oxo-1,2-dihydroquinoline-7-carbonitrile → 1-[2-(4-Aminopiperidin-1-yl)ethyl]-7-bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one

HRID 692582Notes

Reaction equation

HRID 692582 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5]([n:27][cH:28]1)[O:6][CH2:7][C:8](=[O:26])[N:9]2[CH2:10][CH2:11][N:12]1[CH2:13][CH2:14][CH:15]([NH:18][C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:16][CH2:17]1.[NH2:29][CH:30]1[CH2:31][CH2:32][N:33]([CH2:34][CH2:35][n:36]2[c:37]3[c:38]([cH:39][cH:40][c:41]([C:42]#[N:43])[cH:44]3)[cH:45][cH:46][c:47]2=[O:48])[CH2:49][CH2:50]1>>[Br:1][c:2]1[cH:3][c:4]2[c:5]([n:27][cH:28]1)[O:6][CH2:7][C:8](=[O:26])[N:9]2[CH2:10][CH2:11][N:12]1[CH2:13][CH2:14][CH:15]([NH2:18])[CH2:16][CH2:17]1

Participants

3

Reactant 2

HCID 602009201-[2-(4-Aminopiperidin-1-yl)ethyl]-2-oxo-1,2-dihydroquinoline-7-carbonitrileHCID 86642663tert-Butyl{1-[2-(7-bromo-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-1-yl)ethyl]piperidin-4-yl}carbamate

Product 1

HCID 667742821-[2-(4-Aminopiperidin-1-yl)ethyl]-7-bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one

Sources & evidence

ORD record
ord-f76552bab3b7492cab3746c060dd7d4a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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