Stannane, tributyl(1-ethoxyethenyl)- → HCID 57917427, compound

Participants

Reaction Conditions

Reaction Steps

3-(3-Bromo-imidazo[1,2-a]pyridin-6-ylmethyl)-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine (Example 296, 100 mg, 0.245 mmol) was dissolved in dioxane (0.98 mL) in a microwave reactor. Then tributyl(1-ethoxyvinyl)tin (85 μL, 0.245 mmol) and tetrakis(triphenylphosphine)palladium (2.8 mg, 0.002 mmol) were introduced. The RM was heated at 150° C. for 1 h under microwave irradiations. The solvent was removed and the residue was purified by flash chromatography (CombiFlash® Companion System®, with RediSep® silica gel column, 0 to 20% MeOH in DCM). Combined fractions were concentrated and the residue was triturated with Et2O. The precipitate was filtered off and dried to afford the title compound as a white solid (tR 0.7 min (conditions 2), MH+=372).

Provenance & Evidence