4-Bromo-2-fluorobenzoic acid → (8-Bromo-1-methyl-1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-ylidenemethyl)phosphonic acid diethyl ester
Reaction equation
[CH2:1]([CH3:2])[O:3][P:4]([O:5][CH2:6][CH3:7])(=[O:8])[CH:9]=[C:10]1[c:11]2[c:12]([cH:18][cH:19][cH:20][cH:21]2)[N:13]([CH3:17])[CH2:14][CH2:15][NH:16]1.[F:22][c:23]1[cH:24][c:25]([Br:32])[cH:26][cH:27][c:28]1[C:29]([OH:30])=[O:31]>>[CH2:1]([CH3:2])[O:3][P:4]([O:5][CH2:6][CH3:7])(=[O:8])[CH:9]=[C:10]1[c:11]2[c:12]([cH:18][c:19]([Br:32])[cH:20][cH:21]2)[N:13]([CH3:17])[CH2:14][CH2:15][NH:16]1Participants
3
Sources & evidence
- ORD record
- ord-971c17dbbff945e4b43f4932e00ea533
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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