Methanol → Ethyl 1-(4-amino-3-(cyclopropylmethoxy)phenyl)cyclobutanecarboxylate

HRID 693763Notes

Reaction equation

HRID 693763 reaction equation
[CH3:24][OH:25].[CH:1]1([CH2:4][O:5][c:6]2[cH:7][c:8]([C:15]3([C:19](=[O:20])[O:21][CH2:22][CH3:23])[CH2:16][CH2:17][CH2:18]3)[cH:9][cH:10][c:11]2[N+:12]([O-:13])=[O:14])[CH2:2][CH2:3]1.[OH-:26].[OH-:27].[Pd+2:28]>>[CH:1]1([CH2:4][O:5][c:6]2[cH:7][c:8]([C:15]3([C:19](=[O:20])[O:21][CH2:22][CH3:23])[CH2:16][CH2:17][CH2:18]3)[cH:9][cH:10][c:11]2[NH2:12])[CH2:2][CH2:3]1

Participants

5

Reactant 4

HCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 57995510Ethyl 1-(3-(cyclopropylmethoxy)-4-nitrophenyl)cyclobutanecarboxylate

Product 1

HCID 57995499Ethyl 1-(4-amino-3-(cyclopropylmethoxy)phenyl)cyclobutanecarboxylate

Sources & evidence

ORD record
ord-c02a01a8df1e4f2687a78d1cb9ce7bd2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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