Hydrochloric Acid → HCID 68976036, compound

Participants

Reaction Steps

A solution of [(R)-1-(2-chloro-4-nitrophenyl)pyrrolidin-3-yl]methylcarbamic acid tert-butyl ester (560 mg) in dichloromethane (2 mL) was mixed with trifluoroacetic acid (2 mL; alternatively a solution of HCl in dioxane or propanole-2 can be used) and stirred at room temperature for 5 hours. The reaction mixture was partitioned between dichloromethane and sodium carbonate solution. The organic phase was dried and concentrated. The product with the molecular weight of 255.71 (C11H14ClN3O2) was obtained in this way; MS (ESI): 256 (M+H+).

Provenance & Evidence