HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Butoxy-2-(2-chloroethyl)benzoyl chloride → {(R)-1-[4-(6-Butoxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-2-fluorophenyl]pyrrolidin-3-yl}methylcarbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Butoxy-2-(2-chloroethyl)benzoyl chloride | HCID 53440133 | — |
| Reactant | tert-Butyl (R)-[1-(4-amino-2-fluorophenyl)pyrrolidin-3-yl]methylcarbamate | HCID 68988249 | — |
| Product | {(R)-1-[4-(6-Butoxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-2-fluorophenyl]pyrrolidin-3-yl}methylcarbamic acid tert-butyl ester | HCID 68988870 | — |
Reaction Steps
4-Butoxy-2-(2-chloroethyl)benzoyl chloride was reacted by method A with [(R)-1-(4-amino-2-fluorophenyl)pyrrolidin-3-yl]methylcarbamic acid tert-butyl ester. The product with the molecular weight of 511.64 (C29H38FN3O4) was obtained in this way; MS (ESI): 512 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822495B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-69de3f758ca34cd18c6b024b8196e36a |
| Source note | uspto-grants-2014_09 |