HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl vinyl sulfone → 6-Butoxy-2-(3-fluoro-4-{(R)-3-[(2-methanesulfonylethyl)methylamino]pyrrolidin-1-yl}phenyl)-3,4-dihydro-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl vinyl sulfone | HCID 19354 | — |
| Reactant | 6-Butoxy-2-[3-fluoro-4-((R)-3-methylaminopyrrolidin-1-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one | HCID 24859577 | — |
| Product | 6-Butoxy-2-(3-fluoro-4-{(R)-3-[(2-methanesulfonylethyl)methylamino]pyrrolidin-1-yl}phenyl)-3,4-dihydro-2H-isoquinolin-1-one | HCID 24859709 | — |
Reaction Steps
6-Butoxy-2-[3-fluoro-4-((R)-3-methylaminopyrrolidin-1-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one was reacted with methanesulfonylethene by method G. The product with the molecular weight of 517.67 (C27H36FN3O4S) was obtained in this way; MS (ESI): 518 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822495B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-d2c5c17b53004ccd883e72f32cd67d1d |
| Source note | uspto-grants-2014_09 |