2-(2-Chloroethyl)-4-methoxybenzoyl chloride → 2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-6-methoxy-3,4-dihydro-2H-isoquinolin-1-one

Participants

Role	Name	HCID	Charge
Reactant	2-(2-Chloroethyl)-4-methoxybenzoyl chloride	HCID 12401186	—
Reactant	[(R)-1-(4-amino-2-fluorophenyl)pyrrolidin-3-yl]dimethylamine	HCID 68977761	—
Product	2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-6-methoxy-3,4-dihydro-2H-isoquinolin-1-one	HCID 68987954	—

Reaction Steps

2-(2-Chloroethyl)-4-methoxybenzoyl chloride was reacted with [(R)-1-(4-amino-2-fluorophenyl)pyrrolidin-3-yl]dimethylamine by method A. The product with the molecular weight of 383.47 (C22H26FN3O2) was obtained in this way; MS (ESI): 384 (M+H+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08822495B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-f86f2582a82b41dd8e806ccb3599797e
Source note	uspto-grants-2014_09