Formaldehyde → racemic (2'S,3S,4'R)-4'-[5-bromo-2-(1-methyl-4-piperidinyloxy)-phenyl]-6-chloro-2'-(3-fluorophenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione
Reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([O:32][CH:33]2[CH2:34][CH2:35][NH:36][CH2:37][CH2:38]2)[c:6]([CH:8]2[CH2:9][C:10](=[O:31])[NH:11][CH:12]([c:24]3[cH:25][c:26]([F:30])[cH:27][cH:28][cH:29]3)[C:13]23[C:14](=[O:23])[NH:15][c:16]2[cH:17][c:18]([Cl:22])[cH:19][cH:20][c:21]23)[cH:7]1.[CH2:39]=[O:40].[CH3:41][OH:42]>>[Br:1][c:2]1[cH:3][cH:4][c:5]([O:32][CH:33]2[CH2:34][CH2:35][N:36]([CH3:39])[CH2:37][CH2:38]2)[c:6]([CH:8]2[CH2:9][C:10](=[O:31])[NH:11][CH:12]([c:24]3[cH:25][c:26]([F:30])[cH:27][cH:28][cH:29]3)[C:13]23[C:14](=[O:23])[NH:15][c:16]2[cH:17][c:18]([Cl:22])[cH:19][cH:20][c:21]23)[cH:7]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-e3fdd104e7de41fba60e4d05f3a8d817
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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