Tolylboronic acid → 3-Methyl-5-p-tolylthiophene-2-carbaldehyde

HRID 69427Notes

Reaction equation

HRID 69427 reaction equation
Br[C:2]1[S:6][C:5]([CH:7]=[O:8])=[C:4]([CH3:9])[CH:3]=1.[CH3:10][C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1>>[CH3:9][C:4]1[CH:3]=[C:2]([C:14]2[CH:15]=[CH:16][C:11]([CH3:10])=[CH:12][CH:13]=2)[S:6][C:5]=1[CH:7]=[O:8]

Participants

3

Reactant 2

HCID 79799Tolylboronic acidHCID 151154075-Bromo-3-methylthiophene-2-carbaldehyde

Product 1

HCID 866290143-Methyl-5-p-tolylthiophene-2-carbaldehyde

Procedure

5-Bromo-3-methylthiophene-2-carbaldehyde (Spinelli, D. et al., J. Chem. Soc. Perkin Trans. 2, 1972, (12), 1866-9) was reacted with 4-methylphenylboronic acid by method J. The product with the molecular weight of 216.30 (C13H12OS) was obtained in this way; MS (ESI): 217 (M+H+).

Workup

  1. customThe product with the molecular weight of 216.30 (C13H12OS) was obtained in this way

Sources & evidence

ORD record
ord-f20b44f76d09419c9373313e65a961cf
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Reaction notes

Loading…