Carbonate Ion → Isopropyl 4-(1-(4-cyano-2-fluorophenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate

HRID 694359Notes

Reaction equation

HRID 694359 reaction equation
[C:1](#[N:2])[c:3]1[cH:4][c:5]([F:30])[c:6](-[n:9]2[c:10](=[O:29])[cH:11][c:12]([O:15][CH:16]3[CH2:17][CH2:18][N:19]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:20][CH2:21]3)[cH:13][cH:14]2)[cH:7][cH:8]1.[C:68](=[O:69])([O-:70])[O-:71].[Cl:58][c:59]1[n:60][cH:61][c:62]([CH2:63][CH2:64][CH3:65])[cH:66][n:67]1.[Cs+:72].[Cs+:73].[O:31]=[c:32]1[cH:33][c:34]([O:35][CH:36]2[CH2:37][CH2:38][N:39]([C:40]([O:41][C:42]([CH3:43])([CH3:44])[CH3:45])=[O:46])[CH2:47][CH2:48]2)[cH:49][cH:50][n:51]1-[c:52]1[cH:53][n:54][cH:55][cH:56][cH:57]1>>[C:1](#[N:2])[c:3]1[cH:4][c:5]([F:30])[c:6](-[n:9]2[c:10](=[O:29])[cH:11][c:12]([O:15][CH:16]3[CH2:17][CH2:18][N:19]([C:22](=[O:23])[O:24][CH:25]([CH3:26])[CH3:27])[CH2:20][CH2:21]3)[cH:13][cH:14]2)[cH:7][cH:8]1

Participants

6

Reactant 5

HCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 27357842-Chloro-5-propylpyrimidineHCID 57468410Tert-butyl 4-(1-(4-cyano-2-fluorophenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylateHCID 67367446Tert-butyl 4-(2-oxo-1-(pyridin-3-yl)-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate

Product 1

HCID 57468421Isopropyl 4-(1-(4-cyano-2-fluorophenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-92d15782bd8a483bb2682cc2d1a7229a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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