Propane, 1-bromo-3-fluoro- → 2-{4-[(S)-7-(3-Fluoro-propyl)-2,7-diaza-spiro[4.4]non-2-yl]-phenyl}-6-hydroxy-2H-isoquinolin-1-one

Participants

Role	Name	HCID	Charge
Reactant	Propane, 1-bromo-3-fluoro-	HCID 67699	—
Reactant	2-[(S)-4-(2,7-diaza-spiro[4.4]non-2-yl)-phenyl]-6-hydroxy-2H-isoquinolin-1-one	HCID 68990152	—
Product	2-{4-[(S)-7-(3-Fluoro-propyl)-2,7-diaza-spiro[4.4]non-2-yl]-phenyl}-6-hydroxy-2H-isoquinolin-1-one	HCID 68991663	—

Reaction Steps

According to Method X, 2-[(S)-4-(2,7-diaza-spiro[4.4]non-2-yl)-phenyl]-6-hydroxy-2H-isoquinolin-1-one was reacted with 1-bromo-3-fluoro-propane. In this way the product was obtained with molecular weight 421.52 (C25H28FN3O2); MS (ESI): 422 (M+H+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08822495B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-79f1e2bb22db4ae2a40b86b275ef81e7
Source note	uspto-grants-2014_09