HRID69447

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11208

Oxirane, 2,2-dimethyl-

C4H8O

结构：O=c1c2ccc(OCC3CC3)cc2ccn1-c1ccc(N2CCC3(CCNC3)C2)c(F)c1

HCID68991253

未命名化合物

PRODUCTS

生成物

结构：CC(C)(O)CN1CCC2(CCN(c3ccc(-n4ccc5cc(OCC6CC6)ccc5c4=O)cc3F)C2)C1

HCID57916632

未命名化合物

PROCEDURE

实验过程

According to Method U, 6-cyclopropylmethoxy-2-[4-(2,7-diaza-spiro[4.4]non-2-yl)-3-fluorophenyl]-2H-isoquinolin-1-one was reacted with 2,2-dimethyl-oxirane. In this way the product was obtained with molecular weight 505.64 (C30H36FN3O3); MS (ESI): 506 (M+H+).

WORKUP

后处理

customIn this way the product was obtained with molecular weight 505.64 (C30H36FN3O3)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-83dd5c9105af4819a1886264c2585574
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08822495B2
来源说明: uspto-grants-2014_09

反应 SMILES

[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]3[C:13](=[CH:14][CH:15]=2)[C:12](=[O:16])[N:11]([C:17]2[CH:22]=[CH:21][C:20]([N:23]4[CH2:27][CH2:26][C:25]5([CH2:31][CH2:30][NH:29][CH2:28]5)[CH2:24]4)=[C:19]([F:32])[CH:18]=2)[CH:10]=[CH:9]3)[CH2:3][CH2:2]1.[CH3:33][C:34]1([CH3:37])[CH2:36][O:35]1>>[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]3[C:13](=[CH:14][CH:15]=2)[C:12](=[O:16])[N:11]([C:17]2[CH:22]=[CH:21][C:20]([N:23]4[CH2:27][CH2:26][C:25]5([CH2:31][CH2:30][N:29]([CH2:33][C:34]([OH:35])([CH3:37])[CH3:36])[CH2:28]5)[CH2:24]4)=[C:19]([F:32])[CH:18]=2)[CH:10]=[CH:9]3)[CH2:3][CH2:2]1