4-(Benzyloxy)-2-methylbenzoic acid → 4-benzyloxy-N-((R)-4-[1,3']bipyrrolidinyl-1'-yl-3-methoxy-phenyl)-2-methyl-benzamide

HRID 69451Notes

Reaction equation

HRID 69451 reaction equation
[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([OH:15])=O)=[C:11]([CH3:18])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:19]1([C@@H:24]2[CH2:28][CH2:27][N:26]([C:29]3[CH:34]=[CH:33][C:32]([NH2:35])=[CH:31][C:30]=3[O:36][CH3:37])[CH2:25]2)[CH2:23][CH2:22][CH2:21][CH2:20]1>>[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([NH:35][C:32]2[CH:33]=[CH:34][C:29]([N:26]3[CH2:27][CH2:28][C@@H:24]([N:19]4[CH2:20][CH2:21][CH2:22][CH2:23]4)[CH2:25]3)=[C:30]([O:36][CH3:37])[CH:31]=2)=[O:15])=[C:11]([CH3:18])[CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 211943914-(Benzyloxy)-2-methylbenzoic acidHCID 68988063HCID 68988063, compound

Product 1

HCID 689888534-benzyloxy-N-((R)-4-[1,3']bipyrrolidinyl-1'-yl-3-methoxy-phenyl)-2-methyl-benzamide

Procedure

According to Method P, 4-benzyloxy-2-methyl-benzoic acid was reacted with (R)-4-[1,3′]bipyrrolidinyl-1′-yl-3-methoxy-phenylamine. In this way the product was obtained with molecular weight 485.63 (C30H35N3O3); MS (ESI): 486 (M+H+).

Workup

  1. customIn this way the product was obtained with molecular weight 485.63 (C30H35N3O3)

Sources & evidence

ORD record
ord-29eb65fd264f4e88bc5e1094103bc7e4
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Reaction notes

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