Cesium fluoride → 2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluorophenyl)-6-((3R,4R)-4-hydroxy-tetrahydro-pyran-3-yloxy)-2H-isoquinolin-1-one

Participants

Role	Name	HCID	Charge
Reactant	Cesium fluoride	HCID 25953	—
Reactant	3,7-Dioxabicyclo(4.1.0)heptane	HCID 12022131	—
Reactant	2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-hydroxy-2H-isoquinolin-1-one	HCID 68989350	—
Product	2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluorophenyl)-6-((3R,4R)-4-hydroxy-tetrahydro-pyran-3-yloxy)-2H-isoquinolin-1-one	HCID 57916743	—

Reaction Steps

According to Method T, 2-((R)-4-[1,3′]bipyrrolidinyl-1′-yl-3-fluorophenyl)-6-hydroxy-2H-isoquinolin-1-one, with cesium fluoride as auxiliary base, was reacted with 3,7-dioxa-bicyclo[4.1.0]heptane. In this way the product was obtained with molecular weight 493.58 (C28H32FN3O4); MS (ESI): 494 (M+H+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08822495B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-38c45ebef3004b14a3ec6d8818154f6f
Source note	uspto-grants-2014_09