6-Hydroxy-2-{3-methoxy-4-[4-(2-methoxy-1-methyl-ethyl)-[1,4]diazepan-1-yl]-phenyl}-3,4-dihydro-2H-isoquinolin-1-one → 2-{3-Methoxy-4-[4-(2-methoxy-1-methyl-ethyl)-[1,4]diazepan-1-yl]-phenyl}-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one

HRID 69468Notes

Reaction equation

HRID 69468 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([C:13]1[CH:18]=[CH:17][C:16]([N:19]3[CH2:25][CH2:24][CH2:23][N:22]([CH:26]([CH3:30])[CH2:27][O:28][CH3:29])[CH2:21][CH2:20]3)=[C:15]([O:31][CH3:32])[CH:14]=1)[CH2:6][CH2:5]2.CS([CH2:37][C@H:38]1[CH2:42][CH2:41][CH2:40][O:39]1)(=O)=O>>[CH3:32][O:31][C:15]1[CH:14]=[C:13]([N:7]2[CH2:6][CH2:5][C:4]3[C:9](=[CH:10][CH:11]=[C:2]([O:1][CH2:37][C@H:38]4[CH2:42][CH2:41][CH2:40][O:39]4)[CH:3]=3)[C:8]2=[O:12])[CH:18]=[CH:17][C:16]=1[N:19]1[CH2:25][CH2:24][CH2:23][N:22]([CH:26]([CH3:30])[CH2:27][O:28][CH3:29])[CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 689891356-Hydroxy-2-{3-methoxy-4-[4-(2-methoxy-1-methyl-ethyl)-[1,4]diazepan-1-yl]-phenyl}-3,4-dihydro-2H-isoquinolin-1-oneHCID 68993549(R)-2-methanesulfonylmethyl-tetrahydrofuran

Product 1

HCID 579168372-{3-Methoxy-4-[4-(2-methoxy-1-methyl-ethyl)-[1,4]diazepan-1-yl]-phenyl}-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one

Procedure

6-Hydroxy-2-{3-methoxy-4-[4-(2-methoxy-1-methyl-ethyl)-[1,4]diazepan-1-yl]-phenyl}-3,4-dihydro-2H-isoquinolin-1-one and (R)-2-methanesulfonylmethyl-tetrahydrofuran were reacted according to Method K1. In this way the product was obtained with molecular weight 523.68 (C30H41N3O5); MS (ESI): 524 (M+H+).

Workup

  1. customIn this way the product was obtained with molecular weight 523.68 (C30H41N3O5)

Sources & evidence

ORD record
ord-66cab9aaff244343ad74e592e47d8a41
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Reaction notes

Loading…