6-Methoxy-3,4-dihydro-1H-2-benzopyran-1-one → 4-[2-Methoxy-4-(6-methoxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-phenyl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester

HRID 69471Notes

Reaction equation

HRID 69471 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])O[CH2:7][CH2:6]2.[C:14]([O:18][C:19]([N:21]1[CH2:27][CH2:26][CH2:25][N:24]([C:28]2[CH:33]=[CH:32][C:31]([NH2:34])=[CH:30][C:29]=2[O:35][CH3:36])[CH2:23][CH2:22]1)=[O:20])([CH3:17])([CH3:16])[CH3:15]>>[C:14]([O:18][C:19]([N:21]1[CH2:27][CH2:26][CH2:25][N:24]([C:28]2[CH:33]=[CH:32][C:31]([N:34]3[CH2:7][CH2:6][C:5]4[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[CH:4]=4)[C:9]3=[O:13])=[CH:30][C:29]=2[O:35][CH3:36])[CH2:23][CH2:22]1)=[O:20])([CH3:17])([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 124011826-Methoxy-3,4-dihydro-1H-2-benzopyran-1-oneHCID 689879374-(4-Amino-2-methoxyphenyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester

Product 1

HCID 689888154-[2-Methoxy-4-(6-methoxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-phenyl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester

Procedure

6-Methoxy-isochroman-1-one and 4-(4-amino-2-methoxyphenyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester were reacted according to Method AC. In this way the product was obtained with molecular weight 481.60 (C27H35N3O5); MS (ESI): 482 (M+H+).

Workup

  1. customIn this way the product was obtained with molecular weight 481.60 (C27H35N3O5)

Sources & evidence

ORD record
ord-cfe55756085744bf8c0075639a4f6626
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Reaction notes

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