HRID69474

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cc(N2CCc3cc(O)ccc3C2=O)ccc1N1CCCN(CC(C)(C)O)CC1

HCID68987973

未命名化合物

HCID68993549

未命名化合物

PRODUCTS

生成物

结构：COc1cc(N2CCc3cc(OC[C@H]4CCCO4)ccc3C2=O)ccc1N1CCCN(CC(C)(C)O)CC1

HCID57916934

未命名化合物

PROCEDURE

实验过程

6-Hydroxy-2-{4-[4-(2-hydroxy-2-methyl-propyl)-[1,4]diazepan-1-yl]-3-methoxy-phenyl}-3,4-dihydro-2H-isoquinolin-1-one and (R)-2-methanesulfonylmethyl-tetrahydrofuran were reacted according to Method K1. In this way the product was obtained with molecular weight 523.68 (C30H41N3O5); MS (ESI): 524 (M+H+).

WORKUP

后处理

customIn this way the product was obtained with molecular weight 523.68 (C30H41N3O5)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a995647b9ac54af1896fa2c66c9782fc
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08822495B2
来源说明: uspto-grants-2014_09

反应 SMILES

[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([C:13]1[CH:18]=[CH:17][C:16]([N:19]3[CH2:25][CH2:24][CH2:23][N:22]([CH2:26][C:27]([OH:30])([CH3:29])[CH3:28])[CH2:21][CH2:20]3)=[C:15]([O:31][CH3:32])[CH:14]=1)[CH2:6][CH2:5]2.CS([CH2:37][C@H:38]1[CH2:42][CH2:41][CH2:40][O:39]1)(=O)=O>>[OH:30][C:27]([CH3:28])([CH3:29])[CH2:26][N:22]1[CH2:23][CH2:24][CH2:25][N:19]([C:16]2[CH:17]=[CH:18][C:13]([N:7]3[CH2:6][CH2:5][C:4]4[C:9](=[CH:10][CH:11]=[C:2]([O:1][CH2:37][C@H:38]5[CH2:42][CH2:41][CH2:40][O:39]5)[CH:3]=4)[C:8]3=[O:12])=[CH:14][C:15]=2[O:31][CH3:32])[CH2:20][CH2:21]1