6-Hydroxy-2-{4-[4-(2-hydroxy-2-methyl-propyl)-[1,4]diazepan-1-yl]-3-methoxy-phenyl}-3,4-dihydro-2H-isoquinolin-1-one → 2-{4-[4-(2-Hydroxy-2-methyl-propyl)-[1,4]diazepan-1-yl]-3-methoxy-phenyl}-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one

HRID 69474Notes

Reaction equation

HRID 69474 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([C:13]1[CH:18]=[CH:17][C:16]([N:19]3[CH2:25][CH2:24][CH2:23][N:22]([CH2:26][C:27]([OH:30])([CH3:29])[CH3:28])[CH2:21][CH2:20]3)=[C:15]([O:31][CH3:32])[CH:14]=1)[CH2:6][CH2:5]2.CS([CH2:37][C@H:38]1[CH2:42][CH2:41][CH2:40][O:39]1)(=O)=O>>[OH:30][C:27]([CH3:28])([CH3:29])[CH2:26][N:22]1[CH2:23][CH2:24][CH2:25][N:19]([C:16]2[CH:17]=[CH:18][C:13]([N:7]3[CH2:6][CH2:5][C:4]4[C:9](=[CH:10][CH:11]=[C:2]([O:1][CH2:37][C@H:38]5[CH2:42][CH2:41][CH2:40][O:39]5)[CH:3]=4)[C:8]3=[O:12])=[CH:14][C:15]=2[O:31][CH3:32])[CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 689879736-Hydroxy-2-{4-[4-(2-hydroxy-2-methyl-propyl)-[1,4]diazepan-1-yl]-3-methoxy-phenyl}-3,4-dihydro-2H-isoquinolin-1-oneHCID 68993549(R)-2-methanesulfonylmethyl-tetrahydrofuran

Product 1

HCID 579169342-{4-[4-(2-Hydroxy-2-methyl-propyl)-[1,4]diazepan-1-yl]-3-methoxy-phenyl}-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one

Procedure

6-Hydroxy-2-{4-[4-(2-hydroxy-2-methyl-propyl)-[1,4]diazepan-1-yl]-3-methoxy-phenyl}-3,4-dihydro-2H-isoquinolin-1-one and (R)-2-methanesulfonylmethyl-tetrahydrofuran were reacted according to Method K1. In this way the product was obtained with molecular weight 523.68 (C30H41N3O5); MS (ESI): 524 (M+H+).

Workup

  1. customIn this way the product was obtained with molecular weight 523.68 (C30H41N3O5)

Sources & evidence

ORD record
ord-a995647b9ac54af1896fa2c66c9782fc
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Reaction notes

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