6-Hydroxy-2-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one → HCID 57916960, compound

HRID 69476Notes

Reaction equation

HRID 69476 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([C:13]1[CH:18]=[CH:17][C:16]([N:19]3[CH2:25][CH2:24][CH2:23][N:22]([CH3:26])[CH2:21][CH2:20]3)=[CH:15][CH:14]=1)[CH2:6][CH2:5]2.CS([CH2:31][C@H:32]1[CH2:36][CH2:35][CH2:34][O:33]1)(=O)=O>>[CH3:26][N:22]1[CH2:23][CH2:24][CH2:25][N:19]([C:16]2[CH:15]=[CH:14][C:13]([N:7]3[CH2:6][CH2:5][C:4]4[C:9](=[CH:10][CH:11]=[C:2]([O:1][CH2:31][C@H:32]5[CH2:36][CH2:35][CH2:34][O:33]5)[CH:3]=4)[C:8]3=[O:12])=[CH:18][CH:17]=2)[CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 689935356-Hydroxy-2-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-oneHCID 68993549(R)-2-methanesulfonylmethyl-tetrahydrofuran

Product 1

HCID 57916960HCID 57916960, compound

Procedure

6-Hydroxy-2-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one and (R)-2-methanesulfonylmethyl-tetrahydrofuran were reacted according to Method K1. In this way the product was obtained with molecular weight 435.57 (C26H33N3O3); MS (ESI): 436 (M+H+).

Workup

  1. customIn this way the product was obtained with molecular weight 435.57 (C26H33N3O3)

Sources & evidence

ORD record
ord-7bc35f213d944496b5b1860a526a8e02
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Reaction notes

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