4-(4-Methyl-1,4-diazepan-1-yl)aniline → 6-Methoxy-2-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one

HRID 69478Notes

Reaction equation

HRID 69478 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])O[CH:7]=[CH:6]2.[CH3:14][N:15]1[CH2:21][CH2:20][CH2:19][N:18]([C:22]2[CH:27]=[CH:26][C:25]([NH2:28])=[CH:24][CH:23]=2)[CH2:17][CH2:16]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[N:28]([C:25]1[CH:24]=[CH:23][C:22]([N:18]3[CH2:19][CH2:20][CH2:21][N:15]([CH3:14])[CH2:16][CH2:17]3)=[CH:27][CH:26]=1)[CH2:7][CH2:6]2

Participants

3

Reactant 2

HCID 130079514-(4-Methyl-1,4-diazepan-1-yl)anilineHCID 151110126-Methoxyisochromen-1-one

Product 1

HCID 689902646-Methoxy-2-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one

Procedure

6-Methoxy-isochromen-1-one and 4-(4-methyl-[1,4]diazepan-1-yl)-phenylamine were reacted according to Method AC. In this way the product was obtained with molecular weight 365.48 (C22H27N3O2); MS (ESI): 366 (M+H+).

Workup

  1. customIn this way the product was obtained with molecular weight 365.48 (C22H27N3O2)

Sources & evidence

ORD record
ord-3c86aac88a2247bca2d8ea52999b609f
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Reaction notes

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