(2S)-2-Ethyloxirane → HCID 57916931, compound

HRID 69479Notes

Reaction equation

HRID 69479 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([C:13]1[CH:18]=[CH:17][C:16]([N:19]3[CH2:25][CH2:24][CH2:23][N:22]([CH3:26])[CH2:21][CH2:20]3)=[CH:15][CH:14]=1)[CH2:6][CH2:5]2.[O:27]1[C@@H:29]([CH2:30][CH3:31])[CH2:28]1>>[OH:27][C@@H:29]([CH2:30][CH3:31])[CH2:28][O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([C:13]1[CH:14]=[CH:15][C:16]([N:19]3[CH2:25][CH2:24][CH2:23][N:22]([CH3:26])[CH2:21][CH2:20]3)=[CH:17][CH:18]=1)[CH2:6][CH2:5]2

Participants

3

Reactant 2

HCID 10898629(2S)-2-EthyloxiraneHCID 689935356-Hydroxy-2-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one

Product 1

HCID 57916931HCID 57916931, compound

Procedure

6-Hydroxy-2-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one and (S)-(−)-1,2-epoxybutane were reacted according to Method T1. In this way the product was obtained with molecular weight 423.56 (C25H33N3O3); MS (ESI): 424 (M+H+).

Workup

  1. customIn this way the product was obtained with molecular weight 423.56 (C25H33N3O3)

Sources & evidence

ORD record
ord-e574395206564876b1a25f7e43b0fd84
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Reaction notes

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