6-((S)-2-Hydroxybutoxy)isochromen-1-one → 6-((S)-2-Hydroxy-butoxy)-2-[3-methoxy-4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-2H-isoquinolin-1-one

HRID 69489Notes

Reaction equation

HRID 69489 reaction equation
[OH:1][C@@H:2]([CH2:16][CH3:17])[CH2:3][O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[C:11](=[O:15])O[CH:9]=[CH:8]2.[CH3:18][O:19][C:20]1[CH:21]=[C:22]([NH2:34])[CH:23]=[CH:24][C:25]=1[N:26]1[CH2:32][CH2:31][CH2:30][N:29]([CH3:33])[CH2:28][CH2:27]1>>[OH:1][C@@H:2]([CH2:16][CH3:17])[CH2:3][O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[C:11](=[O:15])[N:34]([C:22]1[CH:23]=[CH:24][C:25]([N:26]3[CH2:32][CH2:31][CH2:30][N:29]([CH3:33])[CH2:28][CH2:27]3)=[C:20]([O:19][CH3:18])[CH:21]=1)[CH:9]=[CH:8]2

Participants

3

Reactant 2

HCID 668791856-((S)-2-Hydroxybutoxy)isochromen-1-oneHCID 68992279HCID 68992279, compound

Product 1

HCID 579168616-((S)-2-Hydroxy-butoxy)-2-[3-methoxy-4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-2H-isoquinolin-1-one

Procedure

6-((S)-2-Hydroxy-butoxy)-isochromen-1-one and 3-methoxy-4-(4-methyl-[1,4]diazepan-1-yl)-phenylamine were reacted according to Method AJ. In this way the product was obtained with molecular weight 451.57 (C22H33N3O4); MS (ESI): 452 (M+H+).

Workup

  1. customIn this way the product was obtained with molecular weight 451.57 (C22H33N3O4)

Sources & evidence

ORD record
ord-f084c2874c7c431795f0f4a77f15b974
Source dataset
uspto-grants-2014_09
Patent number
US08822495B2

Reaction notes

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