HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 69490Generated: October 27, 2026
Dimethylformamide → 6-((S)-2-Hydroxybutoxy)isochromen-1-one
https://huagongshe.com/reaction/69490
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | (2S)-2-Ethyloxirane | HCID 10898629 | — |
| Reactant | 6-Hydroxyisochromen-1-one | HCID 66879699 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-((S)-2-Hydroxybutoxy)isochromen-1-one | HCID 66879185 | — |
Reaction Steps
A mixture of 6-Hydroxy-isochromen-1-one (405 mg), (S)-(−)-1,2-epoxybutane (361 mg), cesium fluoride (1.1 g) and DMF (5 mL) was stirred for 4 h at 130° C. After adding water it was extracted with dichloromethane, dried over magnesium sulfate and concentrated. The residue was purified by preparative HPLC. In this way the product was obtained with molecular weight 234.25 (C13H1404); MS (ESI): 235 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08822495B2 |
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| Source dataset | uspto-grants-2014_09 |
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| ORD ID | ord-f1bdf2c6f30a4f709d03ca79a17f77db |
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| Source note | uspto-grants-2014_09 |
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