((3R,4R)-4-methoxy-pyrrolidin-3yl)-dimethylamine → 2-[4-((3R,4R)-3-Dimethylamino-4-methoxy-pyrrolidin-1-yl)-3-fluorophenyl]-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-2H-isoquinolin-1-one

Participants

Role	Name	HCID	Charge
Reactant	((3R,4R)-4-methoxy-pyrrolidin-3yl)-dimethylamine	HCID 68689751	—
Reactant	2-(4-Bromo-3-fluorophenyl)-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-2H-isoquinolin-1-one	HCID 68991216	—
Product	2-[4-((3R,4R)-3-Dimethylamino-4-methoxy-pyrrolidin-1-yl)-3-fluorophenyl]-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-2H-isoquinolin-1-one	HCID 57916866	—

Reaction Steps

2-(4-Bromo-3-fluorophenyl)-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-2H-isoquinolin-1-one and ((3R*,4R*)-4-methoxy-pyrrolidin-3yl)-dimethylamine were reacted according to Method R1. In this way the product was obtained with molecular weight 481.57 (C27H32FN3O4); MS (ESI): 482 (M+H+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08822495B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-32315e8970054af489e0dc5e5eff74f6
Source note	uspto-grants-2014_09